Here, we sought to quantify Th17-related (IL17A, IL22, and RORC), Th1-related (IFNG and IL8), Treg-related (FOXP3 and IL10), and IL-1 family (IL33 and IL36A) skin transcripts and correlate with disease activity, systemic comorbidities, and methotrexate use in samples of Brazilian patients affected by psoriasis. The gene discussed is IL33; the disease is psoriasis.