Here, we sought to quantify Th17-related (IL17A, IL22, and RORC), Th1-related (IFNG and IL8), Treg-related (FOXP3 and IL10), and IL-1 family (IL33 and IL36A) skin transcripts and correlate with disease activity, systemic comorbidities, and methotrexate use in samples of Brazilian patients affected by psoriasis. This evidence concerns the gene IL17A and psoriasis.