Compound 968 and BPTES (bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide) are two allosteric inhibitors of GLS1 that exhibit antitumor activities in numerous pre-clinical studies and several tumor types [100, 108, 121, 255–257]. The gene discussed is GLS; the disease is neoplasm.