This QTL replicated Cath1, a locus for carotid atherosclerosis originally mapped in the B6 × C3H Apoe−/− intercross and then replicated in the B6 × BALB Apoe−/− intercross (Li et al. 2008; Rowlan et al. 2013a). This evidence concerns the gene APOE and carotid atherosclerosis.