Nin, Dact1, and Rtn1, which are located underneath the linkage peak and contain one or more nontolerated nonsynonymous SNPs, have shown suggestive associations with increased risk of ischemic stroke (Meschia et al. 2011) or lipoprotein particle size (Frazier-Wood et al. 2013). Here, DACT1 is linked to ischemic stroke.