The distal locus overlapped with Cath2, mapped initially in the B6 × C3H Apoe−/− intercross as a suggestive QTL for carotid atherosclerosis and then replicated in the B6 × BALB Apoe−/− intercross as a highly significant QTL (Li et al. 2008; Rowlan et al. 2013a). This evidence concerns the gene APOE and carotid atherosclerosis.