Finally, the observation in our cell culture model that CD147 downregulation leads to decreased expression of proteins important for stromal and extracellular matrix remodeling (ECM) such as collagen A1 and TGM2 (Figure 3A and Supplementary Figure 3B) persisted in tumor tissue samples where another ECM component, fibronectin (FN), was also downregulated in CD147 silenced tumors (Supplementary Figure 9D). The gene discussed is FN1; the disease is neoplasm.