We found that BDL-stimulated significant fibrosis and collagen deposition in liver tissues; blockade of IL-17A conspicuously reduced hepatic fibrosis in BDL injured livers as indicated by an improved liver morphology (Figure 1C) and function (Figure 1D), decreased deposition of collagen and expression of α-smooth muscle actin (α-SMA) (Figure 1E). This evidence concerns the gene ACTA1 and Hepatic fibrosis.