Increased expression of IL1RAP and IRAK1 as well as “elevated IRAK1-recruit IKK complex and Mahajan_response_to_IL1A pathway” is also associated with poorer prognosis of AML patients, while the increased expression of IRAK1BP1, a negative regulator of IRAK1 signaling, is correlated to better prognosis (Figure 8B). This evidence concerns the gene IL1RAP and acute myeloid leukemia.