We found that while IL1RA or anti-TNF alone can repress the CFU of LCs, combination treatment significantly enhances the CFU inhibitory activity of the NF-κB inhibitor, suggesting that co-inactivation of IL1 and TNF signaling can significantly sensitize LCs to NF-κB inhibition in HD culture condition (Figure 5A). This evidence concerns the gene IL1B and Huntington disease.