Consistent with this observation, we found that combined treatment with both the NF-κB inhibitor BAY11-7802 (BAY hereafter) and the JNK inhibitor SP600125 (SP hereafter) profoundly reduced the tumor burden and prolonged the survival of leukemic mice developed from MA9 transduction (Figure 1A-1C). The gene discussed is MAPK8; the disease is neoplasm.