To investigate if survivin antagonists YM155 (Sepantronium Bromide) and M4N (Tetra-O-methyl nordihydroguaiaretic acid) affect cell viability of NEC cell lines, we incubated NEC-DUE1 and -2 cells with increasing concentrations of YM155 and M4N, respectively. The gene discussed is BIRC5; the disease is neuroendocrine carcinoma.