TFRC and metastatic malignant neoplasm: As an ideal DOX nanocarrier for our LDNM study, we used H-Ferritin (HFn) nanocages, recently proposed as a promising bionanoparticle for cancer targeting [23] owing to its affinity for transferrin receptor 1 (TfR-1), which is constitutively overexpressed in primary and metastatic cancer cells [24].