In the group with ER/PR negative status, aneuploidy independently predicted recurrence (n=96), with odds ratio (OR) 4.67 (95% CI 1.78 – 12.27, p=0.002; Supplementary Table S2A), and lymph node metastasis (n=76) with OR 5.47 (95% CI 1.58 – 18.99, p=0.007, Supplementary Table S2B). Here, ESR1 is linked to metastatic malignant neoplasm in the lymph nodes.