Abnormal activation of NF-κB is closely implicated in biogenesis of cancer-associated miRNAs such as miR-146a [31, 32], miR-125b [32], miR-155 [33], miR-21 [34], miR-301a [35], miR-9 [36], miR-199a [37], and miR-15/16 cluster [38]. The gene discussed is NFKB1; the disease is cancer.