Taken together, SRSF3 confers malignant phenotypes on cancer cells by upregulating the NF-κB-dependent miR-1908-5p expression and its oncogenic functions are enforced by positive feedback regulation of the NF-κB pathway via the SRSF3/miR-1908-5p/NKIRAS2 axis. The gene discussed is SRSF3; the disease is cancer.