To determine whether methylation of the hOGG1 gene promoter is an alternative mechanism of inactivating hOGG1 mRNA expression, we evaluated mRNA expression after treating NSCLC cell lines with the demethylating agent 5-aza-2’-deoxycytidine (5-Aza) (Figure 3B). The gene discussed is OGG1; the disease is non-small cell lung carcinoma.