1998; Fleidervish et al. 1999; Binshtok et al. 2006). Excessive GluN2C expression in L4 spiny stellate cells (and in L2/3 pyramidal neurons) has been linked to seizure generation in a mouse model of epilepsy (Lozovaya et al. 2014). Extrasynaptically, the lower sensitivity of GluN2C receptors to block by Mg2+ and their higher glutamate sensitivity make them suitable to detect even low levels of ambient glutamate, even when the membrane potential is near rest, leading to changes of the resting potential and hence a modulation of neuronal excitability (Binshtok et al. 2006). Here, GRIN2C is linked to epilepsy.