We defined sets of coding regions for oncoproteins, tumor suppressor proteins, and cytoskeletal‐related proteins that were compared between nonsmokers and smokers, for mutation occurrences, in the lung adenocarcinoma (LUAD), head and neck squamous carcinoma (HNSC), bladder carcinoma (BLCA), and pancreatic adenocarcinoma ( PAAD) datasets from the cancer genome atlas (TCGA). This evidence concerns the gene TCHP and cancer.