Since many pathways in normal stem cells also function in CSCs and iCSCs, including the notable examples of NF-κB, Hedgehog, Notch, and Wnt signaling, the drugs that target these pathways can be used in combination with radio- or chemotherapy to eliminate preexisting CSCs and to prevent the transformation of non-stem cancer cells into iCSCs. The gene discussed is NFKB1; the disease is cancer.