After exerting the multivariate analysis, the nuclear overexpression of OLC1 (HR = 1.39, P = 0.011), along with old age (≥ 60, HR = 1.55, P = 0.019), smoking history (HR = 2.07, P < 0.001), tumor invasion depth (HR = 1.42, P = 0.045), lymph node grade (HR = 1.48, P = 0.002) and metastasis (HR = 4.71, P = 0.005) could be independent prognostic factors for OS of gastric adenocarcinoma patients. Here, IST1 is linked to neoplasm.