The evidence provided by others and the results presented here, collectively, indicate that NEO1 acts by primarily promoting tumoral migration and survival through its ligands produced by the tumoral cells [18], stroma [42], or lamina basal [7], while DCC acts mostly as a pro-apoptotic molecule [43], which expression is reduced in several tumors as NB [31] among others. The gene discussed is DCC; the disease is neuroblastoma.