We found that in addition to playing a role in cell-cell adhesion, knocking down levels of Nectin-4 in the ovarian cancer cells lines CAOV3 and NIH:OVCAR5 affected the formation of multicellular aggregates (i.e. spheroids), and decreased the rates of cell migration, as well as having effects on cell proliferation. This evidence concerns the gene NECTIN4 and ovarian carcinoma.