SOX4 and cancer: The down-regulation of CXCL8 and SOX4 expression in the knockdown cells for GOLGB1 or SF3B3 were further validated by qRT-PCR (Figure 6E), supporting that CXCL8 and SOX4 are the downstream targets of GOLGB1 and SF3B3. Indeed, previous studies have established well that the CXCL8 (IL-8) and SOX4 can promote cancer development and progression [25, 26].