However, the recurrence genes in the previous study i.e. Woo et al. [6] had 15 genes overlapped with RER genes, which included many of the well-known representative markers of HCC recurrence such as CD24 [19], TGFB1 [20], CXCL6 [21], CXCL8 [22], and PKM [23] (Figure 2E). This evidence concerns the gene PKM and hepatocellular carcinoma.