CD38 stimulation has previously been linked to increased sensitivity towards migratory stimuli.[7,22] To test whether SYK is involved in this process, we analyzed the potential of primary CLL cells to migrate towards a CXCL12 gradient with and without previous stimulation with IB4 in the presence and absence of R406. This evidence concerns the gene CXCL12 and B-cell chronic lymphocytic leukemia.