The application of a SAR-guided pose analysis to develop 3D-GRIND models to retrieve the binding hypothesis as well as the 3D structural requirements for inhibitors against the Akt2 PH domain could pave the way towards the design of antagonists specifically directed against the other isoforms of Akt (Akt1-3), and potentially guide the development of cancer-specific chemotherapeutic treatments with limited side effects. Here, AKT2 is linked to cancer.