MARVELD2 and myopathy: The literature was scanned for reports of: (1) Chaperones shown in vivo to function in the folding of abundant muscle proteins, such as CCT/TRiC that is required for actin folding; (2) chaperones known to cause myopathies in humans, such as DNAJB6 (DNJ-24), as well as chaperones that affect C. elegans motility, such as UNC-23; and (3) chaperones that are localized to the sarcomere, such as HSP-12.1 [18, 25, 38, 39, 41–54] (S1 Table).