SIV-specific CD8+ T cell functional responses to Tat-TL8 or Gag-CM9 peptides peaked between 13 and 20dpi in SLT and blood of most animals as shown in S7a Fig, similar to the kinetics of Mamu A*01 tetramer binding (Fig 2a), then subsequently declined in most animals as infection progressed. The gene discussed is TAT; the disease is infection.