SYK and acute disseminated encephalomyelitis: In contrast, no significant difference was seen between ADE (ZGP12/1.1) and non-ADE (CTR IgG) infections in Syk knockdown cells although 2 of the Syk shRNAs (shSyk3 and shSyk4) significantly reduced the expression of the Syk protein (Fig 4B and 4C).