MAPK3 and age-related macular degeneration: Since these angiogenic factors all activate the ras signalling cascade we determined if FR-sema3C can inhibit in cultured human umbilical vein derived endothelial cells (HUVEC) ERK1/2 phosphorylation induced by these factors as a proof of concept in order to determine if FR-sema3C has the potential to inhibit their activity in AMD.