We detected a significant association between high expression of TIP30 and a good OS of patients with esophageal carcinoma (HR = 0.50, 95% CI: 0.29–0.86), laryngeal carcinoma (HR = 0.38, 95% CI: 0.23–0.65), pancreatic adenocarcinoma (HR = 0.60, 95% CI: 0.39–0.92), gastric cancer (HR = 0.18, 95% CI: 0.05–0.65), and gallbladder adenocarcinoma (HR = 0.40, 95% CI: 0.23–0.70). Here, HTATIP2 is linked to pancreatic adenocarcinoma.