Researchers also showed that TIP30 could inhibit snail-mediated epithelial-mesenchymal transition (EMT) and tumor-initiating properties in hepatocellular carcinoma and suppress TGF-β1-induced EMT via AKT/β-catenin signaling in esophageal carcinoma[12,20]. This evidence concerns the gene AKT1 and carcinoma of esophagus.