DNMT1 and central nervous system cancer: Moreover, in the majority of the low-grade gliomas from TCGA samples analyzed, high p-c-Jun was also associated with high CpG methylation, suggesting a possible mechanistic link between p-c-Jun, DNMT1 and G-CIMP (Spearman's ranked correlation between p-c-Jun protein level and CpG methylation and Fisher's exact test for significance niveau p<0.05) (Figure 3C and 3D).