Interestingly, we observed a significant correlation between DNMT1 RNA levels and p-c-Jun in high grade gliomas from TCGA (n=531, Pearson correlation=0.3, Baysian predicted correlation R=0.37 (95%CI 0.21-0.5), Fischer's exact test p= 8,9 x10-5) (Figure 3A–3B). The gene discussed is DNMT1; the disease is central nervous system cancer.