Incubation of immunoprecipitated Hsp90 from K562 chronic leukemia cells or imatinib resistant chronic leukemia cells K562/G01 with 17-AAG or CP interfered with the binding of Hsp90 to biotin-GA modestly, whereas the sequential or simultaneous co-treatment with 17-AAG and CP inhibited the interaction more significantly than single agent treatment. This evidence concerns the gene CP and chronic leukemia.