ERBB3 and breast cancer: Further, we examined LINC00052 expression in breast cancer cells of HER3-high (MCF7), HER3-knockdown (MCF7/HER3 KD) or HER3-low (BT549, MDA-MB-231 and Hs578T) upon stimulation with NRG-1, and results showed that LINC00052 expression was increased in cells with HER3-high but not knockdown- or HER3-low (Figure 2B).