Consistently, our previous study also demonstrated that ATIII insufficiency increased the susceptibility to or severity of AKI, suggesting that ATIII is indispensable in the endogenous defense mechanisms against renal IRI; 3) Circulating ATIII activity in sulodexide-pretreated IRI group was increased compared with vehicle-treated IRI at 3h after reperfusion, which preceded the functional and structure changes of kidney between sulodexide-treated and PBS-treated IRI rats. Here, SERPINC1 is linked to acute kidney injury.