Notably, aberrant expression of five cancer-related genes alcohol dehydrogenase 1B (ADH1B), mitotic checkpoint serine/threonine kinase B (BUB1B), cell division cycle 45 (CDC45), FXYD domain containing ion transport regulator 1 (FXYD1), and kinesin family member 20A (KIF20A) were observed in all 16 cancers. The gene discussed is CDC45; the disease is cancer.