Accumulating evidence suggests that mitochondrial dysfunction induces apoptosis, which kill cancer cells by aurora kinase inhibition [25] and Sun and co-workers also revealed that aurora kinase inhibition led to induction of PUMA, a BH3-only Bcl-2 family protein which mediates the apoptosis initiation in colon cancer cells via mitochondrial pathway [26]. The gene discussed is BCL2; the disease is malignant colon neoplasm.