FBXW7 and colonic neoplasm: To show that the proteasomal degradation dependent regulation of EglN2 by FBW7 may apply for other physiologically relevant system, as a complementary approach, we obtained HCT116 colon cancer cell lines with or without somatic FBW7 knockout and found that EglN2 protein levels was upregulated by MG132 treatment in the cell line contain wild type FBW7, the effect mimicked by FBW7 loss, suggesting that potential EglN2 regulation by FBW7 is mediated by proteasomal degradation pathway (Figure 2D).