Although other studies have shown that high NLR was related to the increasing of monocyte chemotactic protein-1, interleukin-1 receptor α (IL-1R-α), IL-6, IL-7, IL-8, IL-12 and IL-17 in peripheral blood [36, 37], these cytokines could build and keep an immune microenvironment promoting tumor invasion [38]. This evidence concerns the gene CCL2 and neoplasm.