Furthermore, the expression level of FHIT is relatively low in LUAD (mean RPKM=37.04) and its adjacent normal tissues (mean RPKM: 28.49) as well as in LUSC (mean RPKM=17.29) and its adjacent normal tissues (mean RPKM=32.18), which implied that the role of FHIT gene played in NSCLC carcinogenesis need to be further confirmed (Figure 4). The gene discussed is FHIT; the disease is non-small cell lung carcinoma.