The basal level of Akt phosphorylation at S473 was low and not significantly affected by BKM120 treatment in HeLa cells carrying wild-type PIK3CA. These results indicate that PI3K inhibition does not uniformly induce autophagy as a cytoprotective mechanism in all PIK3CA-mutant cervical cancer cell. This evidence concerns the gene AKT1 and cervical carcinoma.