Since 14-3-3ζ is highly associated with tumorigenesis and poor prognosis, and its knockdown increases the efficacy of chemotherapeutic agents [34–36], we here showed that dissociation of FOXO3a from 14-3-3, in particular the 14-3-3ζ isoform, is a key factor in BKM120-induced cytoprotective autophagy in PIK3CA-mutant cancer cells (Figure 5B, , , and 5E). Here, PIK3CA is linked to cancer.