Circulating IGFBP2 levels correlated well with the tumor size (R = 0.241, P = 0.008) (Figure 2), and IGFBP2 levels were significantly higher in larger tumors (> 6 cm) than those of smaller ones (956.8 ± 734.0 ng/ml vs. 548.6 ± 364.0 ng/ml; P = 0.007) (Table 2). Here, IGFBP2 is linked to neoplasm.