In what concerns to sesquiterpene lactones effects on G2/mitosis checkpoint markers, Rozenblat, et al. [36] had demonstrated that tomentosin and inuviscolide increased the protein levels of p21, p-Tyr15-Thr14-CDK1, and cyclin B1 in G2 arrested human melanoma SK-28 cells. Here, CDK1 is linked to melanoma.