After peripheral nerve injury, the generation of a pro-regenerative environment involves the upregulation and secretion of extracellular matrix (ECM) components, such as collagen type IV, laminin and fibronectin, and the secretion of different neurotrophic factors (NTFs), such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and glial derived neurotrophic factor (GDNF), among others [10]. This evidence concerns the gene GDNF and peripheral nerve injury.