Moreover, studies in breast cancer reveal that Forkhead Box F1 (FoxF1) promotes cancer cell migration by upregulating LOX and suppressing Smad2/3 signaling, whereas nuclear factor I-C2 (NFI-C2) suppresses EMT, motility, invasiveness, and tumor growth of breast cancer by downregulating LOX gene expression [71]. The gene discussed is SMAD2; the disease is breast carcinoma.