FoxM1b, a transcription factor often overexpressed in human cancers, enhances LOX and LOXL2 expression by directly binding to the LOX and LOXL2 gene promoters, further activating the downstream AKT-Snail pathway and promoting EMT and hepatocellular carcinoma metastasis [61]. The gene discussed is LOXL2; the disease is hepatocellular carcinoma.