AKT1 and acne: Recent evidence suggests that there is increased phosphoinositide 3-kinase-Akt-mammalian target of rapamycin complex 1 (PI3K-Akt-mTORC1) signaling in the skin of patients with acne vulgaris [18,19,20] and that increased PI3K-Akt-mTORC1 signaling induces sebum production [21].