A contribution of MRP6, a transporter primarily involved in Pseudoxanthoma elasticum, a genetic disease affecting elastic fibers in the body, and whose mRNA expression is well-preserved in HuH-7 cells when compared to human hepatocytes, is also unlikely because there is little evidence that this transporter handles efficiently anionic xenobiotics [57]. This evidence concerns the gene ABCC6 and pseudoxanthoma elasticum (inherited or acquired).