Moreover, we also showed that XN possessed a potent synergism with DOX in MCF-7/ADR cells, and this finding was in line with the previous report that XN may also be a potent chemo- and radio-therapy sensitizer via STAT3 and EGFR suppression [11], however, in addtion to the synergism with chemotherapy, we also revealed that XN could down-regulate the cancer stemness characters in MCF-7/ADR cells, for the first time. The gene discussed is STAT3; the disease is cancer.