PPARs belong to the nuclear family of ligand activated transcription factors and comprise three different isoforms, PPAR-α, PPAR-β/δ, and PPAR-γ [7]., Our group had previously demonstrated the cardioprotective effects of PPAR-α stimulation (by fibrates) by reducing oxidative stress during myocardial ischemia [7,11,14,15]. The gene discussed is PPARA; the disease is myocardial ischemia.