In the current study, HF-fed animals were more obese and insulin-resistant when TAG production was measured, making it more difficult to attribute effects solely to diet alone; (2) Does the physiological reduction in HTP under high-fat/low-carbohydrate diet predispose the liver to impaired TAG export under high lipolysis conditions caused by worsened insulin resistance or frank diabetes? The gene discussed is INS; the disease is hydrops fetalis.