In 2007, Christensen et al. found that α-galactosidase—the lysosomal enzyme that is deficient in Fabry disease—is endocytosed in kidney proximal tubule cells after binding to the cell surface receptor megalin (also named LRP2, low-density lipoprotein receptor-related protein 2), i.e., one of the main receptors involved in the reabsorption of proteins at the kidney proximal tubule [122]. This evidence concerns the gene LRP2 and Fabry disease.