FLT4 and neoplasm: The role of neuropilin-2 as a potential therapeutic target in preventing LN metastasis has been highlighted by the fact that colorectal carcinoma can induce activation of neuropilin-2 in LECs to promote tumor lymphangiogenesis via integrin-α9β1/focal adhesion kinase (FAK)/Erk pathway independent VEGF-C/VEGFR-3 signaling [169].