AKT1 and cancer: Recent advances in the study of LN biology are beginning to yield significant new insights into the mechanism of cancer metastasis and therapeutic implications, in which VEGF-C/VEGFR-3, Notch, TGF-β/BMP, MAPK, PI3K/Akt/mTOR signaling pathways have been described in the control of lymphatic growth and remodeling [31,141,160,175].