SLITRK3, a member of SLIT and neurotropic tyrosine receptor kinase (NTRK) like family (SLITRKs), was upregulated in brain tumour [68], lymphoma [69], and gastrointestinal stromal tumour (GIST) [70], and was one of three genes (RTN4, SLITRK3, and SPON2) found to define a cell differentiation signature for LNCaP cells [47]. This evidence concerns the gene SPON2 and gastrointestinal stromal tumor.