Zhang et al., found that MYCN directly regulates the expression of key splicing factors PTBP1 (polypyrimidine tract binding protein 1) and HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) in high-risk neuroblastoma, leading to increased cell proliferation and poor overall survival [24]. This evidence concerns the gene HNRNPA1 and neuroblastoma.