LIPA and hepatocellular carcinoma: A recent study, however, has challenged this concept: Grumet et al. [72] showed that incubation of human hepatoma cells HepG2 with RE-enriched lipoproteins and the LAL inhibitor LALISTAT 2 led to increased RE content in lysosomal fractions indicating that LAL is involved in the clearance of endocytosed REs.