Under fasting, lipophagy contributes significantly to the breakdown of hepatic triglycerides, contained in cytosolic LDs, since inhibition of autophagy protein 5 (ATG5) leads to triglyceride accumulation in hepatocytes and a phenotype similar to non-alcoholic fatty liver disease (NAFLD) [105,107]. The gene discussed is ATG5; the disease is metabolic dysfunction-associated steatotic liver disease.