In the case of PIAS3, significant differences of nuclear PIAS3 detection were evidenced between the tumor-surrounding brain tissues (58.8%; 10/17) and the classical (21.3%; 13/61; p = 0.000), the large-cell (15.9%; 7/44; p = 0.000) or the nodular medulloblastomas (6.70%; 1/15; p = 0.000). Here, PIAS3 is linked to medulloblastoma with extensive nodularity.