STAT3 and medulloblastoma: As shown in Figure 4, high levels of STAT3 expression and distinct STAT3 nuclear translocation were observed in the three normally cultured medulloblastoma cell lines; the inhibitory effects of resveratrol on STAT3 signaling were evidenced in terms of reduction of STAT3 nuclear immunostaining (Figure 4) and down-regulated STAT3 expression (Figure 5).