Inverse correlation could be established between p-SHP2 (R = −0.35; p = 0.029), SOCS3 (R = 0.495; p = 0.001) or PIAS3 expression (R = −0.352; p = 0.020) and p-STAT3 nuclear translocation in the classic medulloblastomas. This evidence concerns the gene PIAS3 and medulloblastoma.