It was revealed that the frequencies of p-SHP2 cytoplasmic labeling were significantly different between the tumor-surrounding brain tissues (17/17; 100%) and the classical (32/61; 52.5%; p = 0.016), the large-cell (27/44; 61.4%; p = 0.000) or the nodular medulloblastomas (2/15; 13.3%; p = 0.000). Here, PTPN11 is linked to medulloblastoma with extensive nodularity.